Exercise induced reprogramming of circadian metabolism at Novo Nordisk Foundation Center for Basic Metabolic Research

Posted 1 week ago

This is a project proposal for a student opportunity at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR).

Background: Many biological processes are characterized by daily variations that are controlled by the circadian clock. The central clock, located in the hypothalamus, is entrained by light as an external zeitgeber (time-giver), and it contributes to synchronize peripheral clocks in nearly all cells of the body. Other external zeitgebers such as physical exercise is also important for circadian regulation. Nevertheless, the most effective time of day to exercise to achieve beneficial effects on health remains unknown.

The project: This project is designed to test the hypothesis that exercise acts as a zeitgeber for molecular clocks in peripheral tissues and controls the expression of metabolic genes involved in substrate metabolism. We have identified Hypoxia-inducible factor 1-alpha (HIF-1α) as a potential exercise-responsive transcription factors that orchestrate metabolism in skeletal muscle in a time-of-day-dependent manner. This master project will be focused on determining the importance of HIF-1α for exercise induced time-of-day-dependent reprogramming of circadian metabolic pathways, and genetic modified mice will be the main model system.

The student: We are looking for ambitious Master students who are enthusiastic about research, and have the ability to quickly learn and work independently. You will be mentored by a senior scientist in the lab who will train and assist you with directing the research project.

Contact: Associate Professor Jonas T. Treebak (jttreebak@sund.ku.dk) or Postdoc Amy Ehrlich (amy.ehrlich@sund.ku.dk).

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